Redox- and enzyme-responsive fluorescent porous silica nanocarriers for drug delivery

In this work, redox/enzyme-responsive fluorescent porous silica (pSiO2) nanoparticles (NPs) were constructed for drug delivery. The resultant pSiO2 NPs have large-pore core and mesoporous shell with size of 75 nm and present high specific surface area (605 m2 g−1). Oxidized glutathione (GSSG) as linker was conjugated on the surfaces of amino-functionalized porous silica (pSiO2-NH2) NPs by the amide bonds for redox-responsive drug release. Dox is...