The catalytic function of the gephyrin‐binding protein IQSEC3 regulates neurotransmitter‐specific matching of pre‐ and post‐synaptic structures in primary hippocampal cultures

In dissociated neuronal cultures the absence of spatial and temporal cues causes the emergence of mismatched synapses, where post‐synaptic proteins of GABA ergic synapses are in part apposed to glutamatergic pre‐synaptic terminals and vice versa. This mismatch offers an opportunity to study the mechanisms that regulate correct apposition of pre‐ and post‐synaptic elements. We report here that the IQ motif and Sec7 domain‐containing protein 3 (...