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An injectable self-healing hydrogel with adhesive and antibacterial properties effectively promotes wound healing

Published on Dec 1, 2018in Carbohydrate Polymers6.04
· DOI :10.1016/j.carbpol.2018.08.090
Honglei Chen3
Estimated H-index: 3
(SWU: Southwest University),
Junwen Cheng1
Estimated H-index: 1
+ 5 AuthorsFei Lu5
Estimated H-index: 5
(SWU: Southwest University)
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Abstract
Abstract Hydrogels with self-healing capacity can undergo self-repair, establishing safer and longer-lasting products. Hydrogel wound dressings showing self-healing capacity can prolong the lifespan of the material and provide better wound protection. Therefore, in this study, Schiff base reactions (reversible imine linkages) were utilized to design injectable self-healing hydrogels with chitosan and konjac glucomannan. Oxidized konjac glucomannan was used to react with chitosan to form hydrogel. In addition to injectable, self-healing properties, the hydrogels also had adhesive and antibacterial properties, were biocompatible, and promoted wound healing. The inhibition rates of hydrogels against Staphylococcus aureus and Escherichia coli were 96% and 98%, respectively. In addition, microscopy and rheological analyses showed that the hydrogels healed within 4 h without additional exogenous stimulation. Finally, the developed hydrogels were injectable and significantly shortened wound recovery time in a full-thickness skin defect model. Thus, our findings established a novel hydrogel material that may have applications in wound healing.
  • References (46)
  • Citations (9)
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References46
Newest
#1Yani Jiang (YZU: Yangzhou University)H-Index: 2
#2Jiping Zhou (YZU: Yangzhou University)H-Index: 3
Last.Qi Zhang (YZU: Yangzhou University)H-Index: 2
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#1Kun Yu (SWU: Southwest University)H-Index: 6
#2Fei Lu (SWU: Southwest University)H-Index: 5
Last.Guangqian Lan (SWU: Southwest University)H-Index: 7
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#1Wenjie Jian (SCAU: South China Agricultural University)H-Index: 4
#2Liying Tu (JMU: Jimei University)H-Index: 1
Last.Yuanming Sun (SCAU: South China Agricultural University)H-Index: 20
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#1Liu Yuan (Donghua University)H-Index: 3
#2Yu Wu (Donghua University)H-Index: 4
Last.Xiumei Mo (Donghua University)H-Index: 30
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Cited By9
Newest
#1Wanjun Chen (Inner Mongolia University)H-Index: 2
#2Yingnan Zhu (TJU: Tianjin University)
Last.Yan‐Jie Wang (DGUT: Dongguan University of Technology)H-Index: 1
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#1Ying Liang (NU: Nanjing University)H-Index: 2
#2Mingqian Wang (NU: Nanjing University)H-Index: 3
Last.Jian Shen (Nanjing Normal University)H-Index: 19
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#1I. V. Polyakova (RAS: Russian Academy of Sciences)H-Index: 2
#2L. N. Borovikova (RAS: Russian Academy of Sciences)H-Index: 6
Last.O. A. Pisarev (RAS: Russian Academy of Sciences)H-Index: 6
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#1Sepehr Talebian (Illawarra Health & Medical Research Institute)H-Index: 13
#2Mehdi Mehrali (DTU: Technical University of Denmark)
Last.Gorka OriveH-Index: 43
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#1Yun‐Hui Yan (Case Western Reserve University)H-Index: 1
#2Lihan Rong (Case Western Reserve University)
Last.Rigoberto C. Advincula (Case Western Reserve University)H-Index: 4
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