Allergic inflammatory memory in human respiratory epithelial progenitor cells
Abstract
Barrier tissue dysfunction is a fundamental feature of chronic human inflammatory diseases1. Specialized subsets of epithelial cells-including secretory and ciliated cells-differentiate from basal stem cells to collectively protect the upper airway2-4. Allergic inflammation can develop from persistent activation5 of type 2 immunity6 in the upper airway, resulting in chronic rhinosinusitis, which ranges in severity from rhinitis to severe nasal...
Paper Details
Title
Allergic inflammatory memory in human respiratory epithelial progenitor cells
Published Date
Aug 1, 2018
Journal
Volume
560
Issue
7720
Pages
649 - 654
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Notes
History