Original paper

SIRT6 deficiency results in developmental retardation in cynomolgus monkeys

Nature50.50
Volume: 560, Issue: 7720, Pages: 661 - 665
Published: Aug 1, 2018
Abstract
SIRT6 acts as a longevity protein in rodents1,2. However, its biological function in primates remains largely unknown. Here we generate a SIRT6-null cynomolgus monkey (Macaca fascicularis) model using a CRISPR–Cas9-based approach. SIRT6-deficient monkeys die hours after birth and exhibit severe prenatal developmental retardation. SIRT6 loss delays neuronal differentiation by transcriptionally activating the long non-coding RNA H19 (a...
Paper Details
Title
SIRT6 deficiency results in developmental retardation in cynomolgus monkeys
Published Date
Aug 1, 2018
Journal
Volume
560
Issue
7720
Pages
661 - 665
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