Parkin and PINK1 mitigate STING-induced inflammation
Abstract
Although serum from patients with Parkinson’s disease contains elevated levels of numerous pro-inflammatory cytokines including IL-6, TNF, IL-1β, and IFNγ, whether inflammation contributes to or is a consequence of neuronal loss remains unknown1. Mutations in parkin, an E3 ubiquitin ligase, and PINK1, a ubiquitin kinase, cause early onset Parkinson’s disease2,3. Both PINK1 and parkin function within the same biochemical pathway and remove...
Paper Details
Title
Parkin and PINK1 mitigate STING-induced inflammation
Published Date
Aug 22, 2018
Journal
Volume
561
Issue
7722
Pages
258 - 262
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