hTERT promoter mutations in chondrosarcomas associate with progression and disease-related mortality
Abstract
Chondrosarcomas are malignant skeletal tumors with chondroid differentiation. Prognosis is largely dependent on histological grading, which suffer from significant interobserver variability. Telomerase activity and abundant telomerase reverse transcriptase (hTERT) expression has previously been associated with chondrosarcoma grade and metastasis. We therefore analyzed the hTERT promoter in clinicopathologically well-characterized chondrosarcomas...
Paper Details
Title
hTERT promoter mutations in chondrosarcomas associate with progression and disease-related mortality
Published Date
Dec 1, 2018
Journal
Volume
31
Issue
12
Pages
1834 - 1841
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Notes
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