Barrett's oESophagus trial 3 (BEST3): Study protocol for a randomised controlled trial comparing the Cytosponge-TFF3 test with usual care to facilitate the diagnosis of oesophageal pre-cancer in primary care patients with chronic acid reflux

Published on Dec 1, 2018in BMC Cancer2.93
· DOI :10.1186/s12885-018-4664-3
Judith Offman11
Estimated H-index: 11
('KCL': King's College London),
Beth Muldrew1
Estimated H-index: 1
(QMUL: Queen Mary University of London)
+ 14 AuthorsRebecca C. Fitzgerald36
Estimated H-index: 36
(University of Cambridge)
Background Early detection of oesophageal cancer improves outcomes; however, the optimal strategy for identifying patients at increased risk from the pre-cancerous lesion Barrett’s oesophagus (BE) is not clear. The Cytosponge, a novel non-endoscopic sponge device, combined with the biomarker Trefoil Factor 3 (TFF3) has been tested in four clinical studies. It was found to be safe, accurate and acceptable to patients. The aim of the BEST3 trial is to evaluate if the offer of a Cytosponge-TFF3 test in primary care for patients on long term acid suppressants leads to an increase in the number of patients diagnosed with BE.
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