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Barrett's oESophagus trial 3 (BEST3): Study protocol for a randomised controlled trial comparing the Cytosponge-TFF3 test with usual care to facilitate the diagnosis of oesophageal pre-cancer in primary care patients with chronic acid reflux

Published on Dec 1, 2018in BMC Cancer2.93
· DOI :10.1186/s12885-018-4664-3
Judith Offman11
Estimated H-index: 11
('KCL': King's College London),
Beth Muldrew1
Estimated H-index: 1
(QMUL: Queen Mary University of London)
+ 14 AuthorsRebecca C. Fitzgerald36
Estimated H-index: 36
(University of Cambridge)
Abstract
Background Early detection of oesophageal cancer improves outcomes; however, the optimal strategy for identifying patients at increased risk from the pre-cancerous lesion Barrett’s oesophagus (BE) is not clear. The Cytosponge, a novel non-endoscopic sponge device, combined with the biomarker Trefoil Factor 3 (TFF3) has been tested in four clinical studies. It was found to be safe, accurate and acceptable to patients. The aim of the BEST3 trial is to evaluate if the offer of a Cytosponge-TFF3 test in primary care for patients on long term acid suppressants leads to an increase in the number of patients diagnosed with BE.
  • References (24)
  • Citations (4)
References24
Newest
#1Massimiliano di Pietro (University of Cambridge)H-Index: 18
#2Rebecca C. Fitzgerald (University of Cambridge)H-Index: 36
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Last.Rebecca C. Fitzgerald (Medical Research Council)H-Index: 20
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#1Thomas L. Vaughan (UW: University of Washington)H-Index: 54
#2Rebecca C. Fitzgerald (University of Cambridge)H-Index: 20
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#2Irene Debiram-Beecham (University of Cambridge)H-Index: 5
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#1K. Nadine Phoa (UvA: University of Amsterdam)H-Index: 9
#2Frederike G. Van Vilsteren (UvA: University of Amsterdam)H-Index: 12
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49 CitationsSource
#1Rebecca C. Fitzgerald (University of Cambridge)H-Index: 36
#2Massimiliano di Pietro (University of Cambridge)H-Index: 18
Last.John de Caestecker (University of Leicester)H-Index: 8
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563 CitationsSource
Cited By4
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#1Selena Li (Harvard University)
#2David C. Chung (Harvard University)H-Index: 58
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