Unification of an empirical and a physically-based approach to crystallization monitoring

A population balance model (PBM) and an empirical method using a mass-count plot (MC plot) were developed for batch paracetamol crystallization by previous researchers. The PBM can describe the crystallization process provided that appropriate nucleation and growth kinetics are available; use of the MC plot facilitates feedback control of the crystal mass and total chord counts in the system. In this research, these two approaches have been...