Shedding of BAFF/APRIL Receptors Controls B Cells

Proteolytic shedding of the receptors BCMA, TACI, and BAFFR reduces their cell-surface expression and ligand-mediated survival of B cell subsets. This shedding is executed by protease γ-secretase or by metalloproteases, and is partially dependent on ligand binding and receptor interactions. Shed receptors may serve as biomarkers for autoimmunity and lymphoma. Proteolytic shedding of the receptors BCMA, TACI, and BAFFR reduces their cell-surface...