Preparation of bispecific antibody-protein adducts by site-specific chemo-enzymatic conjugation
Abstract
Historically, bispecific antibodies have been constructed through the genetic fusion of additional binding domains to the constant domains of the antibody heavy- or light chains. We present an alternative method for the introduction of additional functional domains to an antibody: site-specific chemo-enzymatic conjugation. This method relies on the combination of site-specific transpeptidases and bioorthogonal chemistry. Transpeptidases are used...
Paper Details
Title
Preparation of bispecific antibody-protein adducts by site-specific chemo-enzymatic conjugation
Published Date
Feb 1, 2019
Journal
Volume
154
Pages
93 - 101
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