Senescence and senotherapeutics: a new field in cancer therapy
Abstract
Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal activation during embryonic development or normal adult life is linked with beneficial properties. In contrast, persistent (chronic) senescence seems to exert detrimental effects fostering aging and age-related disorders, such as cancer. Due to the lack of a reliable marker able to detect senescence in vivo, its precise impact in age-related diseases is to a...
Paper Details
Title
Senescence and senotherapeutics: a new field in cancer therapy
Published Date
Jan 1, 2019
Journal
Volume
193
Pages
31 - 49
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