Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans
Abstract
During development, neurons form synapses with their fate-determined targets. While we begin to elucidate the mechanisms by which extracellular ligand-receptor interactions enhance synapse specificity by inhibiting synaptogenesis, our knowledge about their intracellular mechanisms remains limited. Here we show that Rap2 GTPase (rap-2) and its effector, TNIK (mig-15), act genetically downstream of Plexin (plx-1) to restrict presynaptic assembly...
Paper Details
Title
Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans
Published Date
Jul 31, 2018
Journal
Volume
7
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