Differential effects of Foxp2 disruption in distinct motor circuits
Abstract
Disruptions of the FOXP2 gene cause a speech and language disorder involving difficulties in sequencing orofacial movements. FOXP2 is expressed in cortico-striatal and cortico-cerebellar circuits important for fine motor skills, and affected individuals show abnormalities in these brain regions. We selectively disrupted Foxp2 in the cerebellar Purkinje cells, striatum or cortex of mice and assessed the effects on skilled motor behaviour using an...
Paper Details
Title
Differential effects of Foxp2 disruption in distinct motor circuits
Published Date
Aug 14, 2018
Journal
Volume
24
Issue
3
Pages
447 - 462
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