Alpha‐Synuclein Modulates the Physical Properties of DNA

Fundamental research on Parkinson's disease (PD) most often focuses on the ability of α‐synuclein (aS) to form oligomers and amyloids, and how such species promote brain cell death. However, there are indications that aS also plays a gene‐regulatory role in the cell nucleus. Here, the interaction between monomeric aS and DNA in vitro has been investigated with single‐molecule techniques. Using a nanofluidic channel system, it was discovered that...