Insulin regulates glucagon-like peptide-1 secretion by pancreatic alpha cells

Volume: 62, Issue: 2, Pages: 394 - 403
Published: Aug 6, 2018
Abstract
Proglucagon is expressed in both pancreatic alpha cells and intestinal epithelial L cells and is cleaved into glucagon and glucagon-like peptide-1 (GLP-1) by different prohormone convertases (PCs). Recent studies have shown that α-cells can also secrete GLP-1, which may improve islet function. However, little is known about the factors influencing GLP-1 secretion by α cells. In this study, we investigated whether insulin promotes GLP-1 secretion...
Paper Details
Title
Insulin regulates glucagon-like peptide-1 secretion by pancreatic alpha cells
Published Date
Aug 6, 2018
Journal
Volume
62
Issue
2
Pages
394 - 403
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