Identification and Analysis of Islet Antigen–Specific CD8+ T Cells with T Cell Libraries

Volume: 201, Issue: 6, Pages: 1662 - 1670
Published: Sep 15, 2018
Abstract
Type 1 diabetes (T1D) is most likely caused by killing of β cells by autoreactive CD8+ T cells. Methods to isolate and identify these cells are limited by their low frequency in the peripheral blood. We analyzed CD8+ T cells, reactive with diabetes Ags, with T cell libraries and further characterized their phenotype by CyTOF using class I MHC tetramers. In the libraries, the frequency of islet Ag–specific CD45RO+IFN-γ+CD8+ T cells was higher in...
Paper Details
Title
Identification and Analysis of Islet Antigen–Specific CD8+ T Cells with T Cell Libraries
Published Date
Sep 15, 2018
Volume
201
Issue
6
Pages
1662 - 1670
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