Spatio-Temporal Expression and Functional Analysis of miR-206 in Developing Orofacial Tissue

Background: Development of the mammalian palate is dependent on precise, spatiotemporal expression of a panoply of genes. MicroRNAs (miRNAs), the largest family of noncoding RNAs, function as crucial modulators of cell and tissue differentiation, regulating expression of key downstream genes. </P><P> Observations: Our laboratory has previously identified several developmentally regulated miRNAs, including miR-206, during critical...