Regarding the Robustness of Results for “Association of Tryptophan Metabolites with Incident Type 2 Diabetes in the PREDIMED Trial: A Case–Cohort Study”

To the Editor: An update to the primary PREDIMED study was recently published to take into account some departures from the individual randomization protocol affecting only a small subset of participants (1). Specifically, ( a ) some participants were not individually randomized because they were members of the same household of a previous participant and they were allocated during the duration of the trial to the same arm as their previously...