Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
Abstract
Cancer treatment by immune checkpoint blockade (ICB) can bring long-lasting clinical benefits, but only a fraction of patients respond to treatment. To predict ICB response, we developed TIDE, a computational method to model two primary mechanisms of tumor immune evasion: the induction of T cell dysfunction in tumors with high infiltration of cytotoxic T lymphocytes (CTL) and the prevention of T cell infiltration in tumors with low CTL level. We...
Paper Details
Title
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
Published Date
Aug 20, 2018
Journal
Volume
24
Issue
10
Pages
1550 - 1558
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