Abstract 3376: Early onset of chromosomal instability in breast preneoplasia detected by single-cell genomics
Abstract
Chromosomal rearrangements and copy number aberrations are a major mechanism for driver gene alterations in breast cancer. However, the origins of chromosomal instability during breast tumorigenesis are poorly understood. We have recently shown that oncogene expression in normal mammary epithelial cells induces replication stress and a DNA damage response (DDR). The double-strand break sensor Mre11 is required for the oncogene-induced DDR, and...
Paper Details
Title
Abstract 3376: Early onset of chromosomal instability in breast preneoplasia detected by single-cell genomics
Published Date
Jul 1, 2018
Journal
Volume
78
Issue
13_Supplement
Pages
3376 - 3376
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Notes
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