IFNγ — link between infections and cardiometabolic risk?

Published on Oct 1, 2018in Nature Reviews Endocrinology24.65
· DOI :10.1038/s41574-018-0078-1
Christian Herder62
Estimated H-index: 62
(HHU: University of Düsseldorf)
Viral infections induce muscle insulin resistance in mice through the stimulation of IFNγ. This results in increased insulin levels, which promote antiviral CD8+ T cell activation. In obese mice, insulin resistance triggered by IFNγ also leads to deterioration of glycaemic control. These findings highlight the intricate link between the immune system and metabolic regulation.
  • References (10)
  • Citations (1)
Published on Sep 1, 2018in Nature Reviews Immunology44.02
Lionel B. Ivashkiv59
Estimated H-index: 59
(Cornell University)
IFNγ is a cytokine with important roles in tissue homeostasis, immune and inflammatory responses and tumour immunosurveillance. Signalling by the IFNγ receptor activates the Janus kinase (JAK)–signal transducer and activator of transcription 1 (STAT1) pathway to induce the expression of classical interferon-stimulated genes that have key immune effector functions. This Review focuses on recent advances in our understanding of the transcriptional, chromatin-based and metabolic mechanisms that und...
Published on Jul 1, 2018in Immunity21.52
Marko Šestan4
Estimated H-index: 4
(University of Rijeka),
Sonja Marinović2
Estimated H-index: 2
(University of Rijeka)
+ 8 AuthorsFelix M. Wensveen18
Estimated H-index: 18
(University of Rijeka)
Summary Pro-inflammatory cytokines of a T helper-1-signature are known to promote insulin resistance (IR) in obesity, but the physiological role of this mechanism is unclear. It is also unknown whether and how viral infection induces loss of glycemic control in subjects at risk for developing diabetes mellitus type 2 (DM2). We have found in mice and humans that viral infection caused short-term systemic IR. Virally-induced interferon-γ (IFN-γ) directly targeted skeletal muscle to downregulate th...
Published on Jan 12, 2018in Diabetes Care15.27
Iain M. Carey31
Estimated H-index: 31
(St George's, University of London),
Julia Critchley30
Estimated H-index: 30
(St George's, University of London)
+ 3 AuthorsDerek G. Cook62
Estimated H-index: 62
(St George's, University of London)
OBJECTIVE We describe in detail the burden of infections in adults with diabetes within a large national population cohort. We also compare infection rates between patients with type 1 and type 2 diabetes mellitus (T1DM and T2DM). RESEARCH DESIGN AND METHODS A retrospective cohort study compared 102,493 English primary care patients aged 40–89 years with a diabetes diagnosis by 2008 ( n = 5,863 T1DM and n = 96,630 T2DM) with 203,518 age-sex-practice–matched control subjects without diabetes. Inf...
Published on Dec 28, 2017in The Journal of Clinical Endocrinology and Metabolism5.61
Magda Cepeda3
Estimated H-index: 3
(EUR: Erasmus University Rotterdam),
Taulant Muka16
Estimated H-index: 16
(EUR: Erasmus University Rotterdam)
+ 2 AuthorsJosje D. Schoufour14
Estimated H-index: 14
(EUR: Erasmus University Rotterdam)
Published on Sep 21, 2017in The New England Journal of Medicine70.67
Paul M. Ridker192
Estimated H-index: 192
Brendan M. Everett31
Estimated H-index: 31
+ 25 AuthorsStefan D. Anker120
Estimated H-index: 120
BackgroundExperimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. MethodsWe conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The ...
Published on Nov 1, 2016in European Journal of Endocrinology5.11
Christian Herder62
Estimated H-index: 62
(HHU: University of Düsseldorf),
Kristine Færch23
Estimated H-index: 23
+ 8 AuthorsMika Kivimaeki118
Estimated H-index: 118
Objective: Higher systemic levels of proinflammatory biomarkers and low adiponectin are associated with increased risk for type 2 diabetes, but their associations with changes in glycaemic deterioration before onset of diabetes are poorly understood. We aimed to study whether inflammation-related biomarkers associated with 5-year changes in glucose and insulin, HbA1c, insulin sensitivity and beta-cell function before the diagnosis of type 2 diabetes and whether these associations may be bidirect...
Published on Jul 1, 2016in The Lancet Diabetes & Endocrinology24.54
Eric Nou9
Estimated H-index: 9
(Harvard University),
Janet Lo25
Estimated H-index: 25
(Harvard University)
+ 1 AuthorsSteven Grinspoon79
Estimated H-index: 79
(Harvard University)
Summary Results from several studies have suggested that people with HIV have an increased risk of cardiovascular disease, especially coronary heart disease, compared with people not infected with HIV. People living with HIV have an increased prevalence of traditional cardiovascular disease risk factors, and HIV-specific mechanisms such as immune activation. Although older, more metabolically harmful antiretroviral regimens probably contributed to the risk of cardiovascular disease, new data sug...
Published on Oct 1, 2015in Trends in Endocrinology and Metabolism9.78
Christian Herder62
Estimated H-index: 62
(HHU: University of Düsseldorf),
Elise Dalmas7
Estimated H-index: 7
+ 1 AuthorsMarc Y. Donath57
Estimated H-index: 57
Patients with type 2 diabetes (T2D) exhibit chronic activation of the innate immune system in pancreatic islets, in insulin-sensitive tissues, and at sites of diabetic complications. This results from a pathological response to overnutrition and physical inactivity seen in genetically predisposed individuals. Processes mediated by the proinflammatory cytokine interleukin-1 (IL-1) link obesity and dyslipidemia and have implicated IL-1β in T2D and related cardiovascular complications. Epidemiologi...
Published on Apr 1, 2015in Nature Immunology23.53
Felix M. Wensveen18
Estimated H-index: 18
(University of Rijeka),
Vedrana Jelenčić5
Estimated H-index: 5
(University of Rijeka)
+ 10 AuthorsF. Thomas Wunderlich19
Estimated H-index: 19
(MPG: Max Planck Society)
Visceral adipose tissue (VAT) inflammation drives obesity-induced insulin resistance. Polic and colleagues show that VAT NK cells sense obesity-induced adipose tissue stress and drive inflammation through the production of interferon-γ.
Cited By1
Published on May 1, 2019in Trends in Endocrinology and Metabolism9.78
Christian Herder62
Estimated H-index: 62
Michael Roden66
Estimated H-index: 66
(HHU: University of Düsseldorf),
Dan Ziegler49
Estimated H-index: 49
The most prevalent chronic complications of diabetes are diabetic neuropathies, among which distal sensorimotor polyneuropathy (DSPN) and cardiovascular autonomic neuropathy (CAN) are the best studied. Their major clinical sequelae such as foot ulcers, neuropathic pain, and orthostatic hypotension are associated with lower quality of life and increased risk of mortality. Here we discuss the recent insights into DSPN and CAN focusing on two prospective cohorts; that is, the German Diabetes Study ...