Personalized cancer neoantigen vaccines come of age
Abstract
Cancer vaccines have encountered their ideal personalized partner along with evidence for great breakthroughs in the identification and synthesis of neoantigens. Individual cancer neoantigen vaccines are capable of eliciting robust T-cell responses and have been demonstrated to achieve striking clinical efficacy due to their high immunogenicity and central thymic tolerance escape of neoantigens. Two recent phase I clinical trials have provided...
Paper Details
Title
Personalized cancer neoantigen vaccines come of age
Published Date
Jan 1, 2018
Journal
Volume
8
Issue
15
Pages
4238 - 4246
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