Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy
Abstract
Alternative oxidases (AOXs) bypass respiratory complexes III and IV by transferring electrons from coenzyme Q directly to O2. They have therefore been proposed as a potential therapeutic tool for mitochondrial diseases. We crossed the severely myopathic skeletal muscle-specific COX15 knockout (KO) mouse with an AOX-transgenic mouse. Surprisingly, the double KO-AOX mutants had decreased lifespan and a substantial worsening of the myopathy...
Paper Details
Title
Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy
Published Date
Nov 1, 2018
Journal
Volume
28
Issue
5
Pages
764 - 775.e5
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