Neutrophil cytoplasts induce T H 17 differentiation and skew inflammation toward neutrophilia in severe asthma
Abstract
Severe asthma is a debilitating and treatment refractory disease. As many as half of these patients have complex neutrophil-predominant lung inflammation that is distinct from milder asthma with type 2 eosinophilic inflammation. New insights into severe asthma pathogenesis are needed. Concomitant exposure of mice to an aeroallergen and endotoxin during sensitization resulted in complex neutrophilic immune responses to allergen alone during later...
Paper Details
Title
Neutrophil cytoplasts induce T H 17 differentiation and skew inflammation toward neutrophilia in severe asthma
Published Date
Aug 3, 2018
Journal
Volume
3
Issue
26
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