Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?

Volume: 30, Issue: 3, Pages: 281 - 289
Published: Aug 15, 2018
Abstract
GPVI is the major signalling receptor for collagen on platelets. Dimerization of GPVI is required for collagen binding and initiation of signalling through the associated FcR-γ chain. Recently, fibrin and fibrinogen have been identified as ligands for GPVI and shown to induce signalling in support of thrombus formation and stabilization. Contrasting observations have been reported on whether fibrin binds to monomeric or dimeric GPVI, or to...
Paper Details
Title
Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?
Published Date
Aug 15, 2018
Journal
Volume
30
Issue
3
Pages
281 - 289
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