Abstract LB-A28: Super-enhancer signatures of pancreatic ductal adenocarcinoma and associated fibroblasts

Therapeutic targeting of super-enhancers (SEs) has emerged as a promising approach for cancer treatment. To understand how SEs regulate the gene expression of tumors and their microenvironments, we sought to profile the SE landscape in pancreatic ductal adenocarcinoma (PDAC) cell lines and cancer-associated fibroblast (CAF) cells that were derived from different PDAC patients. The global profiling of the H3K27Ac signals in 6 PDAC and 6 CAF cell...