Assessing mitochondrial heteroplasmy using next generation sequencing: A note of caution
Abstract
The mitochondrial genome has recently become the focus of several high-impact next-generation sequencing studies investigating the effect of mutations in disease and assessing the efficacy of mitochondrial replacement therapies. However, these studies have failed to take into consideration the capture of recurring translocations of mitochondrial DNA to the nuclear genome, known as nuclear mitochondrial sequences (NUMTs), continuing to align...
Paper Details
Title
Assessing mitochondrial heteroplasmy using next generation sequencing: A note of caution
Published Date
May 1, 2019
Journal
Volume
46
Pages
302 - 306
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