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Abstract 17447: Experimental Sleep Curtailment Increases 24 - Hour Ambulatory Blood Pressure in Healthy Individuals

Published on Nov 11, 2016in Circulation23.054
Naima Covassin12
Estimated H-index: 12
,
Jan Bukartyk10
Estimated H-index: 10
+ 4 AuthorsVirend K. Somers100
Estimated H-index: 100
Abstract
Introduction: Voluntary sleep curtailment is escalating in the general population. Mounting epidemiological research identifies chronic sleep deficiency as an independent determinant of cardiovascular diseases, with compelling evidence linking short sleep to incident hypertension. Nonetheless, experimental data supporting a causal relationship are scarce. Hypothesis: We tested the hypothesis that exposure to experimental prolonged sleep restriction would raise 24-hour ambulatory blood pressure (BP) and that this elevation would be driven by baroreflex impairment. Methods: Fourteen healthy subjects (6 male, age 24±1 years, body mass index 24±1 kg/m2) completed a randomized, controlled, crossover study comprising a 4-day acclimation period, followed by 9 days of experimental sleep restriction (4 hours of sleep/night) or normal sleep, and a 3-day recovery period. Twenty-four hour ambulatory blood pressure monitoring was performed repeatedly throughout the 16-day inpatient protocol. Spontaneous baroreflex sen...
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