Antidepressive and anxiolytic effects of ostruthin, a TREK-1 channel activator
Abstract
We screened a library of botanical compounds purified from plants of Vietnam for modulators of the activity of a two-pore domain K+ channel, TREK-1, and we identified a hydroxycoumarin-related compound, ostruthin, as an activator of this channel. Ostruthin increased whole-cell TREK-1 channel currents in 293T cells at a low concentration (EC50 = 5.3 μM), and also activity of the TREK-2 channel (EC50 = 3.7 mM). In contrast, ostruthin inhibited...
Paper Details
Title
Antidepressive and anxiolytic effects of ostruthin, a TREK-1 channel activator
Published Date
Aug 15, 2018
Journal
Volume
13
Issue
8
Pages
e0201092 - e0201092
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