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Published on Sep 1, 2017in Cell Metabolism22.41
Megan N. Roberts1
Estimated H-index: 1
(UC Davis: University of California, Davis),
Marita A. Wallace3
Estimated H-index: 3
(UC Davis: University of California, Davis)
+ 17 AuthorsTrina A. Knotts14
Estimated H-index: 14
(UC Davis: University of California, Davis)
Summary Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation. The objective of this study was to mimic this metabolic shift using low-carbohydrate diets and to determine the influence of these diets on longevity and healthspan in mice. C57BL/6 mice were assigned to a ketogenic, low-carbohydrate, or control diet at 12 months of age and were either allowed to live their natural lifespan or tested fo...
Published on Sep 1, 2017in Cell Metabolism22.41
John C. Newman19
Estimated H-index: 19
(UCSF: University of California, San Francisco),
Anthony J. Covarrubias1
Estimated H-index: 1
(Buck Institute for Research on Aging)
+ 6 AuthorsEric Verdin95
Estimated H-index: 95
(UCSF: University of California, San Francisco)
Summary Ketogenic diets recapitulate certain metabolic aspects of dietary restriction such as reliance on fatty acid metabolism and production of ketone bodies. We investigated whether an isoprotein ketogenic diet (KD) might, like dietary restriction, affect longevity and healthspan in C57BL/6 male mice. We find that Cyclic KD, KD alternated weekly with the Control diet to prevent obesity, reduces midlife mortality but does not affect maximum lifespan. A non-ketogenic high-fat diet (HF) fed simi...
Published on Aug 1, 2017in Molecular metabolism6.18
Yuanqing Gao12
Estimated H-index: 12
(UvA: University of Amsterdam),
Maximilian Bielohuby16
Estimated H-index: 16
(LMU: Ludwig Maximilian University of Munich)
+ 16 AuthorsErwin Zinser1
Estimated H-index: 1
(FH Joanneum)
Abstract Objective The hypothalamus of hypercaloric diet-induced obese animals is featured by a significant increase of microglial reactivity and its associated cytokine production. However, the role of dietary components, in particular fat and carbohydrate, with respect to the hypothalamic inflammatory response and the consequent impact on hypothalamic control of energy homeostasis is yet not clear. Methods We dissected the different effects of high-carbohydrate high-fat (HCHF) diets and low-ca...
Published on Jul 1, 2017in Cell Metabolism22.41
Martin Valdearcos11
Estimated H-index: 11
(UCSF: University of California, San Francisco),
John D. Douglass4
Estimated H-index: 4
(UW: University of Washington)
+ 8 AuthorsJoshua P. Thaler25
Estimated H-index: 25
(UW: University of Washington)
Summary Dietary excess triggers accumulation of pro-inflammatory microglia in the mediobasal hypothalamus (MBH), but the components of this microgliosis and its metabolic consequences remain uncertain. Here, we show that microglial inflammatory signaling determines the immunologic response of the MBH to dietary excess and regulates hypothalamic control of energy homeostasis in mice. Either pharmacologically depleting microglia or selectively restraining microglial NF-κB-dependent signaling sharp...
Published on Aug 1, 2016in The American Journal of Clinical Nutrition6.57
Kevin D. Hall37
Estimated H-index: 37
(NIH: National Institutes of Health),
Kong Y. Chen31
Estimated H-index: 31
(NIH: National Institutes of Health)
+ 8 AuthorsB. Timothy Walsh57
Estimated H-index: 57
(Columbia University)
Abstract The carbohydrate-insulin model of obesity posits that habitual consumption of a high-carbohydrate diet sequesters fat within adipose tissue because of hyperinsulinemia and results in adaptive suppression of energy expenditure (EE). Therefore, isocaloric exchange of dietary carbohydrate for fat is predicted to result in increased EE, increased fat oxidation, and loss of body fat. In contrast, a more conventional view that "a calorie is a calorie" predicts that isocaloric variations in di...
Published on Dec 1, 2015in Nature43.07
Sagar P. Bapat1
Estimated H-index: 1
Jae Myoung Suh7
Estimated H-index: 7
+ 12 AuthorsChristopher Liddle43
Estimated H-index: 43
Fat-resident regulatory T cells (fTreg cells) accumulate in adipose tissue of mice as a function of age, but not obesity; mice without fTreg cells are protected against age-associated insulin resistance, but remain susceptible to obesity-associated insulin resistance and metabolic disease, indicating different aetiologies of age-associated versus obesity-associated insulin resistance.
Published on Sep 9, 2015in Science Translational Medicine17.16
Guenther Boden63
Estimated H-index: 63
(TU: Temple University),
Carol J. Homko35
Estimated H-index: 35
(TU: Temple University)
+ 6 AuthorsSalim Merali20
Estimated H-index: 20
(TU: Temple University)
Obesity-linked insulin resistance greatly increases the risk for type 2 diabetes, hypertension, dyslipidemia, and non-alcoholic fatty liver disease, together known as the metabolic or insulin resistance syndrome. How obesity promotes insulin resistance remains incompletely understood. Plasma concentrations of free fatty acids and proinflammatory cytokines, endoplasmic reticulum ( ER) stress, and oxidative stress are all elevated in obesity and have been shown to induce insulin resistance. Howeve...
Published on Jun 3, 2015in Science Translational Medicine17.16
Teri A. Manolio101
Estimated H-index: 101
(NIH: National Institutes of Health),
Marc Abramowicz34
Estimated H-index: 34
(ULB: Université libre de Bruxelles)
+ 41 AuthorsRex L. Chisholm49
Estimated H-index: 49
(NU: Northwestern University)
Around the world, innovative genomic-medicine programs capitalize on singular capabilities arising from local health care systems, cultural or political milieus, and unusual selected risk alleles or disease burdens. Such individual efforts might benefit from the sharing of approaches and lessons learned in other locales. The U.S. National Human Genome Research Institute and the National Academy of Medicine recently brought together 25 of these groups to compare projects, to examine the current s...
Published on Apr 1, 2015in Diabetes7.20
Siew Hung Chin2
Estimated H-index: 2
(UZH: University of Zurich),
Flurin Item8
Estimated H-index: 8
(Boston Children's Hospital)
+ 7 AuthorsDaniel Konrad27
Estimated H-index: 27
(UZH: University of Zurich)
Reduced kidney mass and/or function may result in multiple metabolic derangements, including insulin resistance. However, underlying mechanisms are poorly understood. Herein, we aimed to determine the impact of reduced kidney mass on glucose metabolism in lean and obese mice. To that end, seven-week-old C57BL6/J mice underwent uninephrectomy (UniNx) or sham operation. After surgery, animals were fed either a chow (standard) or a high fat diet (HFD) and glucose homeostasis was assessed 20 weeks a...
Published on Oct 1, 2013in Laboratory Animals1.12
Tl Jensen1
Estimated H-index: 1
(Novo Nordisk),
Mk Kiersgaard2
Estimated H-index: 2
(Novo Nordisk)
+ 1 AuthorsLars Friis Mikkelsen5
Estimated H-index: 5
Fasting of mice is a common procedure performed in association with many different types of experiments mainly in order to reduce variability in investigatory parameters or to facilitate surgical procedures. However, the effects of fasting not directly related to the investigatory parameters are often ignored. The aim of this review is to present and summarize knowledge about the effects of fasting of mice to facilitate optimization of the fasting procedure for any given study and thereby maximi...
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