Deletion of GARP on mouse regulatory T cells is not sufficient to inhibit the growth of transplanted tumors
Abstract
GARP is a transmembrane protein that presents latent TGF-β1 on the surface of regulatory T cells (Tregs). Neutralizing anti-GARP monoclonal antibodies that prevent the release of active TGF-β1, inhibit the immunosuppressive activity of human Tregs in vivo. In this study, we investigated the contribution of GARP on mouse Tregs to immunosuppression in experimental tumors. Unexpectedly, Foxp3 conditional garp knockout (KO) mice challenged...
Paper Details
Title
Deletion of GARP on mouse regulatory T cells is not sufficient to inhibit the growth of transplanted tumors
Published Date
Oct 1, 2018
Journal
Volume
332
Pages
129 - 133
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