The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair
Abstract
Covalent DNA-protein cross-links (DPCs) impede replication fork progression and threaten genome integrity. Using Xenopus egg extracts, we previously showed that replication fork collision with DPCs causes their proteolysis, followed by translesion DNA synthesis. We show here that when DPC proteolysis is blocked, the replicative DNA helicase CMG (CDC45, MCM2-7, GINS), which travels on the leading strand template, bypasses an intact leading strand...
Paper Details
Title
The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair
Published Date
Jan 1, 2019
Journal
Volume
176
Issue
1-2
Pages
167 - 181.e21
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