Ancestry-dependent Enrichment of Deleterious Homozygotes in Runs of Homozygosity

Pages: 382721
Published: Aug 1, 2018
Abstract
Runs of homozygosity (ROH) are important genomic features that manifest when an individual inherits two haplotypes that are identical-by-descent. Their length distributions are informative about population history, and their genomic locations are useful for mapping recessive loci contributing to both Mendelian and complex disease risk. We have previously shown that ROH, and especially long ROH that are likely the result of recent parental...
Paper Details
Title
Ancestry-dependent Enrichment of Deleterious Homozygotes in Runs of Homozygosity
Published Date
Aug 1, 2018
Journal
Pages
382721
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