Single and combined effects of selected haloacetonitriles in a human-derived hepatoma line

Haloacetonitriles (HANs) are nitrogenous disinfection byproducts (N-DBPs) detected in drinking water that have high toxicity and are a high risk to human health. The cytotoxicity and genotoxicity as well as the oxidative stress of five HANs, namely chloroacetonitrile (CAN), dichloroacetonitrile (DCAN), trichloroacetonitrile (TCAN), bromoacetonitrile (BAN), and dibromoacetonitrile (DBAN) on a hepatoma cell line (HepG2) were determined by single,...