Machine-Learning-Guided Mutagenesis for Directed Evolution of Fluorescent Proteins
Abstract
Molecular evolution based on mutagenesis is widely used in protein engineering. However, optimal proteins are often difficult to obtain due to a large sequence space. Here, we propose a novel approach that combines molecular evolution with machine learning. In this approach, we conduct two rounds of mutagenesis where an initial library of protein variants is used to train a machine-learning model to guide mutagenesis for the second-round...
Paper Details
Title
Machine-Learning-Guided Mutagenesis for Directed Evolution of Fluorescent Proteins
Published Date
Aug 13, 2018
Journal
Volume
7
Issue
9
Pages
2014 - 2022
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