Original paper

CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10

Published: Aug 28, 2018
Abstract
Mutations in paralogous mitochondrial proteins CHCHD2 and CHCHD10 cause autosomal dominant Parkinson Disease (PD) and Amyotrophic Lateral Sclerosis/Frontotemporal Dementia (ALS/FTD), respectively. Using newly generated CHCHD2, CHCHD10 and CHCHD2/10 double knockout cell lines, we find that the proteins are partially functionally redundant, similarly distributed throughout the mitochondrial cristae, and form heterodimers. Unexpectedly, we also...
Paper Details
Title
CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10
Published Date
Aug 28, 2018
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