STAC3 incorporation into skeletal muscle triads occurs independent of the dihydropyridine receptor
Abstract
Excitation-contraction (EC) coupling in skeletal muscles operates through a physical interaction between the dihydropyridine receptor (DHPR), acting as a voltage sensor, and the ryanodine receptor (RyR1), acting as a calcium release channel. Recently, the adaptor protein SH3 and cysteine-rich containing protein 3 (STAC3) has been identified as a myopathy disease gene and as an additional essential EC coupling component. STAC3 interacts with DHPR...
Paper Details
Title
STAC3 incorporation into skeletal muscle triads occurs independent of the dihydropyridine receptor
Published Date
Aug 2, 2018
Volume
233
Issue
12
Pages
9045 - 9051
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