The Molecular Intersection Between Senescence and Major Depression in the Elderly

Major depressive disorder in the elderly—or late-life depression (LLD)—is one of the most common mental illnesses in the aging population. LLD has several negative effects on health and well-being. Individuals with LLD have an elevated risk of chronic and persistent depressive symptoms as well as high rates of treatment resistance. They also have a higher risk of developing cognitive impairment with progression to dementia and higher rates of...