In silico study for evaluating the binding mode and interaction of 1, 2, 4-triazole and its derivatives as potent inhibitors against Lipoate protein B (LipB)

Tuberculosis (TB) is an infectious disease caused by bacterium specie known as Mycobacterium tuberculosis. Emergence of multi-drug resistant strains of M. tuberculosis led to the development of new and more potent anti-tuberculosis agents. A novel series of 1, 2, 4-triazole derivatives have been reported as better anti-tubercular agents. Thus, Lipoate biosynthesis protein B (LipB) was selected as a potential drug target and docked with the...