Synthesis & molecular modeling studies of bronchodilatory active indole–pyridine conjugates

Aim: Synthesis of novel bronchodilatory active indole–pyridine conjugates. Results/methodology: Indole–pyridine conjugates (6a–n, 8a–i and 10a–c) were synthesized in a facile pathway through reaction of 2-[(1-alkyl-1H-indol-3-yl)methylene]malononitriles 4a,b with the corresponding ketone-containing compounds (5a–f, 7a–c and 9a,b) in the presence of sodium alkoxide. Single (6l, 8 g) and powder (6k, 8d) x-ray studies supported the structures....