In vivo targeted single-nucleotide editing in zebrafish
Abstract
To date, several genome editing technologies have been developed and are widely utilized in many fields of biology. Most of these technologies, if not all, use nucleases to create DNA double-strand breaks (DSBs), raising the potential risk of cell death and/or oncogenic transformation. The risks hinder their therapeutic applications in humans. Here, we show that in vivo targeted single-nucleotide editing in zebrafish, a vertebrate model...
Paper Details
Title
In vivo targeted single-nucleotide editing in zebrafish
Published Date
Jul 30, 2018
Journal
Volume
8
Issue
1
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