Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
Abstract
Receptor activator of NFkB ligand (RANKL) is a TNF-family cytokine required for osteoclast formation, as well as immune cell and mammary gland development. It is produced as a membrane-bound protein that can be shed to form a soluble protein. We created mice harboring a sheddase-resistant form of RANKL, in which soluble RANKL is undetectable in the circulation. Lack of soluble RANKL does not affect bone mass or structure in growing mice but...
Paper Details
Title
Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
Published Date
Jul 25, 2018
Journal
Volume
9
Issue
1
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