An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities
Abstract
Base editor technology, which uses CRISPR-Cas9 to direct cytidine deaminase enzymatic activity to specific genomic loci, enables the highly efficient introduction of precise cytidine-to-thymidine DNA alterations. However, existing base editors create unwanted C-to-T alterations when more than one C is present in the enzyme's five-base-pair editing window. Here we describe a strategy for reducing bystander mutations using an engineered human...
Paper Details
Title
An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities
Published Date
Jul 30, 2018
Journal
Volume
36
Issue
10
Pages
977 - 982
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