Mebendazole stimulates CD14+ myeloid cells to enhance T-cell activation and tumour cell killing

Volume: 9, Issue: 56, Pages: 30805 - 30813
Published: Jul 20, 2018
Abstract
Mebendazole (MBZ) was recently shown to induce a tumor suppressive M1 phenotype in THP-1 monocytes and macrophages. In the present study the immune effects of MBZ was further investigated using human peripheral blood mononuclear cells (PBMCs) co-cultured with tumour cells. The Biomap platform was used to screen for biomarkers induced from MBZ exposed co-cultures of T-cell receptor activated PBMCs, HT29 colon cancer cells and either human...
Paper Details
Title
Mebendazole stimulates CD14+ myeloid cells to enhance T-cell activation and tumour cell killing
Published Date
Jul 20, 2018
Journal
Volume
9
Issue
56
Pages
30805 - 30813
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