Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis.
Abstract
Hepatic lipogenesis is aberrantly induced in nonalcoholic fatty liver disease (NAFLD) via activation of the LXR-SREBP1c pathway. To date, a number of protein factors impinging on the transcriptional activity of LXR and SREBP1c have been elucidated. However, whether this regulatory axis interfaces with long noncoding RNAs (lncRNAs) remains largely unexplored. Here we show that hepatic expression of the lncRNA Blnc1 is strongly elevated in obesity...
Paper Details
Title
Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis.
Published Date
Jul 30, 2018
Journal
Volume
9
Issue
1
Pages
2986 - 2986
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Notes
History