Match!

Can Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio, and Platelet-to-Lymphocyte Ratio at Day +100 be used as a prognostic marker in Multiple Myeloma patients with autologous transplantation?

Published on Sep 1, 2018in Clinical Transplantation1.667
· DOI :10.1111/ctr.13359
S Medeni Solmaz , Celal Acar2
Estimated H-index: 2
+ 10 AuthorsGüner Hayri Özsan5
Estimated H-index: 5
(Dokuz Eylül University)
Abstract
  • References (26)
  • Citations (0)
📖 Papers frequently viewed together
1 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References26
Newest
Despite the advent of novel therapies and improvements in survival, multiple myeloma (MM) remains an incurable disease. Thus, new treatment strategies including immunotherapies are needed for MM patients with stable disease after induction chemotherapy as well as for disease control in patients with advanced disease. However, profound immune dysregulation not only of B cells, but also of other immune cells such as natural killer cells, T cells, and dendritic cells and increase in the number of i...
7 CitationsSource
#1Satoshi Takagi (Harvard University)H-Index: 4
#2Shokichi Tsukamoto (Harvard University)H-Index: 2
Last. Irene M. Ghobrial (Harvard University)H-Index: 67
view all 17 authors...
Purpose: Tumor cell–platelet interactions contribute to tumor progression and metastasis in solid tumors. However, the role of platelets in hematological malignancies is not clear. We investigated the association of platelet activation status with clinical stages in multiple myeloma (MM) patients and explored the role of platelets in MM progression. Experimental Design: Platelets were obtained from healthy donors and MM patients. We examined platelet activation status in MM patients by flow cyto...
6 CitationsSource
#1Huaqin ZuoH-Index: 2
#2Lili ZhaiH-Index: 1
Last. Peipei XuH-Index: 5
view all 5 authors...
Background: Increased neutrophil-to-lymphocyte ratio (NLR) has been proposed to predict poor prognosis in many cancer types. However, the prognostic value of NLR in multiple myeloma (MM) remains largely unknown. This study aimed to investigate whether NLR is an independent predictor of MM. Methods: Data were collected retrospectively from 136 patients who were diagnosed with MM and subjected to bortezomib-thalidomide-dexamethasone chemotherapy at the Nanjing Drum Tower Hospital from 2008 to 2016...
1 CitationsSource
#1Shidai MuH-Index: 3
#2Lisha AiH-Index: 7
Last. Yu HuH-Index: 19
view all 5 authors...
2 CitationsSource
#1Yanjie LiH-Index: 3
#2Hujun LiH-Index: 3
Last. Zhenyu LiH-Index: 12
view all 9 authors...
2 CitationsSource
#1Dae Sik Kim (KU: Korea University)H-Index: 6
#2Eun Sang Yu (KU: Korea University)H-Index: 3
Last. Byung Soo Kim (KU: Korea University)H-Index: 23
view all 8 authors...
2 CitationsSource
#1Lihui ShiH-Index: 5
#2Xiaoqi QinH-Index: 5
Last. Gang AnH-Index: 14
view all 19 authors...
// Lihui Shi 1, * , Xiaoqi Qin 1, 2, * , Huijun Wang 1 , Yonghui Xia 1 , Yuanyuan Li 1 , Xuejing Chen 1 , Lei Shang 1 , Yu-Tzu Tai 3 , Xiaoyan Feng 1 , Prakrati Acharya 4 , Chirag Acharya 3 , Yan Xu 1 , Shuhui Deng 1 , Mu Hao 1 , Dehui Zou 1 , Yaozhong Zhao 1 , Kun Ru 1 , Lugui Qiu 1 , Gang An 1 1 State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China 2 Department of...
18 CitationsSource
#1Josee-Lyne Ethier (U of T: University of Toronto)H-Index: 4
#2Danielle N. Desautels (Sunnybrook Health Sciences Centre)H-Index: 3
Last. Eitan Amir (U of T: University of Toronto)H-Index: 34
view all 5 authors...
Background The presence of a high neutrophil-to-lymphocyte ratio (NLR) has been associated with increased mortality in several malignancies. Here, we quantify the effect of NLR on survival in patients with breast cancer, and examine the effect of clinicopathologic factors on its prognostic value.
63 CitationsSource
Object Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are simple, inexpensive prognostic markers for various conditions. The objective of this study was to determine the prognostic significance of NLR and PLR in patients with multiple myeloma (MM) in terms of survival. Method A retrospective chart review study was conducted for 175 patients who met the criterion of diagnosis for MM between January 2004 and September 2014. Result The median age of diagnosis was 69 yea...
5 CitationsSource
#1Miyoung Kim (Hallym University)H-Index: 4
#2영수 주 (Hallym University)H-Index: 6
Last. Young Kyung Lee (Hallym University)H-Index: 18
view all 10 authors...
Miyoung Kim, M.D., Young-Su Ju, M.D., Eun Jin Lee, M.D., Hee Jung Kang, M.D., Han-Sung Kim, M.D., Hyoun Chan Cho, M.D., Hyo Jung Kim, M.D., Jung-Ah Kim, M.D., Dong Soon Lee, M.D., and Young Kyung Lee, M.D. Departments of Laboratory Medicine, Occupational and Environmental Medicine, and Internal Medicine, Hallym University College of Medicine, Anyang; Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul; Cancer Research Institute, Seoul National University Colle...
1 CitationsSource
Cited By0
Newest
#1Alessandra Romano (University of Catania)H-Index: 16
#2Nunziatina Parrinello (University of Catania)H-Index: 16
Last. Vitina GriecoH-Index: 9
view all 19 authors...
To understand neutrophil impairment in the progression from MGUS through active MM, we investigated the function of mature, high-density neutrophils (HDNs), isolated from peripheral blood. In 7 MM, 3 MGUS and 3 healthy subjects by gene expression profile, we identified a total of 551 upregulated and 343 downregulated genes in MM-HDN, involved in chemokine signaling pathway and FC-gamma receptor mediated phagocytosis conveying in the activation of STAT proteins. In a series of 60 newly diagnosed ...
Source