Can Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio, and Platelet-to-Lymphocyte Ratio at Day +100 be used as a prognostic marker in Multiple Myeloma patients with autologous transplantation?

Published on Sep 1, 2018in Clinical Transplantation 1.52
· DOI :10.1111/ctr.13359
Serife Solmaz Medeni1
Estimated H-index: 1
Celal Acar2
Estimated H-index: 2
+ 10 AuthorsGüner Hayri Özsan5
Estimated H-index: 5
(Dokuz Eylül University)
  • References (26)
  • Citations (0)
Published on Mar 1, 2016in Biochimica et Biophysica Acta 3.44
MengJie Yan2
Estimated H-index: 2
(University of Alberta),
Paul Jurasz21
Estimated H-index: 21
Abstract Platelets are increasingly being recognized for promoting tumor growth and metastasis. Many cells derived from solid tumors have the ability to aggregate platelets, and this ability correlates with their metastatic potential. Over the past half century, our understanding of tumor cell-induced platelet aggregation (TCIPA) has grown beyond the simple concept that tumor cell-containing microthrombi mechanically embolize the microvasculature. Tumor cell-activated platelets secrete a multitu...
40 Citations Source Cite
Published on Jun 15, 2013in Cancer 6.54
Michael J. Proctor9
Estimated H-index: 9
(University of Glasgow),
Paul G. Horgan40
Estimated H-index: 40
(University of Glasgow)
+ 3 AuthorsDonald C. McMillan66
Estimated H-index: 66
(University of Glasgow)
BACKGROUND The modified Glasgow Prognostic Score (mGPS), an inflammation-based prognostic score that uses thresholds of C-reactive protein (> 10 mg/L) and albumin (< 35 g/L), has been found to be independently prognostic of survival in patients with cancer. The objective of the current study was to establish whether the addition of a differential leukocyte count and a high-sensitivity C-reactive protein measurement enhanced the prognostic value of the mGPS. METHODS A total of 12,119 patients who...
54 Citations Source Cite
Published on Nov 1, 2015in Annals of Hematology 2.85
A. Romano1
Estimated H-index: 1
(Johns Hopkins University),
Nunziatina Parrinello15
Estimated H-index: 15
+ 8 AuthorsFrancesco Di Raimondo49
Estimated H-index: 49
Recent reports identify the ratio between absolute neutrophil count (ANC) and absolute lymphocyte count (ALC), called neutrophil to lymphocyte ratio (NLR), as a predictor of progression-free survival (PFS) and overall survival (OS) in various malignancies. We retrospectively examined the NLR in a cohort of 309 newly diagnosed multiple myeloma (MM) patients treated upfront with novel agents. NLR was calculated using data obtained from the complete blood count (CBC) at diagnosis and subsequently c...
12 Citations Source Cite
Published on Jul 3, 2015in Leukemia & Lymphoma 2.64
Bhumsuk Keam27
Estimated H-index: 27
(Seoul National University Hospital),
Hyerim Ha2
Estimated H-index: 2
(Seoul National University Hospital)
+ 5 AuthorsDae Seog Heo45
Estimated H-index: 45
(Seoul National University Hospital)
The purpose of this study was to analyze the pre- and post-treatment neutrophil to lymphocyte ratio (pre- and post-NLR) in combination with immunologic profiles in patients with diffuse large B-cell lymphoma (DLBCL) treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). A total of 447 newly diagnosed patients with DLBCL treated with R-CHOP were analyzed retrospectively. A pre-NLR ≥ 3 was independently associated with poor progression-free survival (PFS) (haza...
18 Citations Source Cite
Published on Aug 1, 2013in Cancer Treatment Reviews 8.12
Donald C. McMillan66
Estimated H-index: 66
(Glasgow Royal Infirmary)
Since the initial work, a decade ago that the combination of C-reactive protein and albumin, the Glasgow Prognostic Score (GPS), had independent prognostic value in patients with cancer, there have been more than 60 studies (>30,000 patients) that have examined and validated the use of the GPS or the modified GPS (mGPS) in a variety of cancer scenarios. The present review provides a concise overview of these studies and comments on the current and future clinical utility of this simple objective...
404 Citations Source Cite
Published on May 1, 2014in Annals of Hematology 2.85
Engin Kelkitli4
Estimated H-index: 4
Hilmi Atay4
Estimated H-index: 4
+ 4 AuthorsMehmet Turgut6
Estimated H-index: 6
(Ondokuz Mayıs University)
The neutrophil/lymphocyte ratio (NLR) at diagnosis has been shown to be a prognostic factor for survival in solid tumors. The NLR at diagnosis as a prognostic factor for multiple myeloma (MM) has not been studied. Therefore, the focus of the study was the correlation of NLR with the proven prognostic parameters in patients with MM. A total of 151 MM patients who fulfilled the International Myeloma Working Group (IMWG) criteria were enrolled in the study by a retrospective review of the patients'...
23 Citations Source Cite
Published on Jan 1, 2008in Oncogene 6.85
Claudio Scavelli8
Estimated H-index: 8
Beatrice Nico55
Estimated H-index: 55
+ 11 AuthorsAngelo Vacca62
Estimated H-index: 62
Bone marrow macrophages of patients with active and nonactive multiple myeloma (MM), monoclonal gammopathies of undetermined significance (MGUS) and benign anemia (controls) were stimulated for 7 days with vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), and analysed for the expression of endothelial cell (EC) markers by reverse transcription (RT)–PCR, real-time RT–PCR, western blot and immunofluorescence. Their vasculogenic ability was investigated in vitro i...
81 Citations Source Cite
Published on Feb 1, 2015in Oncology Letters 1.66
Nian Liu3
Estimated H-index: 3
(Capital Medical University),
Hebing Zhou2
Estimated H-index: 2
(Capital Medical University)
+ 4 AuthorsWenming Chen4
Estimated H-index: 4
(Capital Medical University)
Genetic abnormalities in patients with multiple myeloma (MM) are important risk factors in terms of prognosis. In the present study, the prognostic value of several common MM genetic abnormalities was investigated. Interphase fluorescence in situ hybridization (iFISH) was used to detect genetic abnormalities, including 1q21 gain, t(4;14), t(11;14), t(14;16) and 17p13 deletion in 131 patients. A total of 46.6% patients were detected with one or more abnormalities using iFISH analysis. The 1q21 ga...
10 Citations Source Cite
Published on Apr 11, 2013in Blood 15.13
Gullu Gorgun28
Estimated H-index: 28
(Harvard University),
Gregory Whitehill1
Estimated H-index: 1
(Harvard University)
+ 7 AuthorsPaul G. Richardson152
Estimated H-index: 152
(Harvard University)
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous, immature myeloid cell population with the ability to suppress immune responses. MDSCs have been characterized in infections, inflammatory diseases, and solid tumors; however, their presence and role in the tumor-promoting, immune-suppressive microenvironment in hematologic malignancies remains unclear. We assessed the presence, frequency, and functional characteristics of MDSCs in patients with newly diagnosed, relapsed, and relapsed/...
157 Citations Source Cite
Published on Mar 1, 2010in Cell 31.40
Sergei I. Grivennikov35
Estimated H-index: 35
(University of California, San Diego),
Florian R. Greten37
Estimated H-index: 37
(Technische Universität München),
Michael Karin207
Estimated H-index: 207
(University of California, San Diego)
Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and responses to therapy. Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the molecular events that mediate this dialog have been revealed. This review outlines the principal mechanisms that govern the effects of inflammatio...
4,144 Citations Source Cite
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