Can Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio, and Platelet-to-Lymphocyte Ratio at Day +100 be used as a prognostic marker in Multiple Myeloma patients with autologous transplantation?

Published on Sep 1, 2018in Clinical Transplantation1.667
· DOI :10.1111/ctr.13359
S Medeni Solmaz , Celal Acar2
Estimated H-index: 2
+ 10 AuthorsGüner Hayri Özsan5
Estimated H-index: 5
(Dokuz Eylül University)
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To understand neutrophil impairment in the progression from MGUS through active MM, we investigated the function of mature, high-density neutrophils (HDNs), isolated from peripheral blood. In 7 MM, 3 MGUS and 3 healthy subjects by gene expression profile, we identified a total of 551 upregulated and 343 downregulated genes in MM-HDN, involved in chemokine signaling pathway and FC-gamma receptor mediated phagocytosis conveying in the activation of STAT proteins. In a series of 60 newly diagnosed ...