Accessing Structure, Dynamics and Function of Biological Macromolecules by NMR Through Advances in Isotope Labeling

NMR spectroscopy has become an indispensable tool for high-resolution structure determination of biomolecules at physiological conditions both in solutions and solids. Currently, NMR is routinely used to study the structure and dynamics of high molecular weight biomolecules in sizes ranging up to ~ 50–100 kDa and to evaluate complexes as large as 500–1 MDa. The latest advances in spectrometer technology, methodologies and advents in newer and...