Original paper

Transient activation of AMPK preceding left ventricular pressure overload reduces adverse remodeling and preserves left ventricular function

Volume: 33, Issue: 1, Pages: 711 - 721
Published: Jul 19, 2018
Abstract
Coordinated changes in signaling pathways and gene expression in hearts subjected to prolonged stress maintain cardiac function. Loss of steroid receptor coactivator-2 (SRC-2) results in a reversal to the fetal gene program and disrupts the response to pressure overload, accompanied by prominent effects on metabolism and growth signaling, including increased AMPK activation. We proposed that early metabolic stress driven by AMPK activation...
Paper Details
Title
Transient activation of AMPK preceding left ventricular pressure overload reduces adverse remodeling and preserves left ventricular function
Published Date
Jul 19, 2018
Volume
33
Issue
1
Pages
711 - 721
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