Novel salts of dipicolinic acid as viscosity modifiers for high concentration antibody solutions
Volume: 548, Issue: 1, Pages: 682 - 688
Published: Sep 1, 2018
Abstract
Concentrated monoclonal antibody (mAb) solutions can lead to high viscosity as a result of protein-protein interactions and pose challenges for manufacture. Dipicolinic acid (DPA, pyridine-2,6-dicarboxylic acid) is a potential excipient for reduction of protein solution viscosity and here we describe new DPA salts with improved aqueous solubility. Crystallinity and solubility screens identified ethanolamine and diethanolamine as two promising...
Paper Details
Title
Novel salts of dipicolinic acid as viscosity modifiers for high concentration antibody solutions
Published Date
Sep 1, 2018
Volume
548
Issue
1
Pages
682 - 688
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